I had originally written a small Journal post on this series on DeviantART, roughly half an hour after finishing the thirteenth episode, but there was something about the post and my wording that I didn't like and couldn't manage to fix, so I tossed it into the digital trash bin. Here I am, giving it another shot, but this has also given me time to think back on the series and have a more objective viewpoint. I tend to be in "fanboy" mode when I finish any series, and the whole "OMG that was awesome" factor tends to show a lot ;)
Ultimately, I am disappointed by Fractale. It was a series I was very much looking forward to watching, after seeing the English trailer for it on the Tales of Vesperia: The First Strike DVD (which, while I'm on the subject, I quite like).
Basically, I find the trailer better than the series. This is actually the first anime I've watched that hasn't made it onto the Re-watch list. Every other series has been a favourite, from Haruhi to Shana to Steins;Gate and back.
The trailer made me think the series was a combination of elements from one of Isaac Asimov's visions